KMID : 0607520220300020155
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Korean Journal of Psychosomatic Medicine 2022 Volume.30 No. 2 p.155 ~ p.164
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The Association Between Neurodegenerative Diseases and Development of Type 2 Diabetes
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Koo Sang-Woo
Lee Ho-Jun Kim Yang-Tae Kim Hee-Cheol
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Abstract
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Objectives£ºA growing body of evidence links type 2 diabetes (T2D) with a neurodegenerative disease (ND) such as Alzheimer¡¯s disease and Parkinson¡¯s disease. The purpose of this study is to investigate the relationship between NDs and the development of T2D by comparing the incidence of T2D in a group of various NDs (ND group) and control group.
Methods£ºA population-based 10-year follow-up study was conducted using the Korean National Health Information Database for 2002-2015. We used a retrospective cohort study design to investigate the association of ND with T2D occurrence. The study population included ND (n=8,814) and control (n=37,970) groups, all aged 60 years or over. The Kaplan-Meier method was used to estimate the risk of developing T2D as a function of time. Cox proportional hazards regression models were used to evaluate the relationship between ND and T2D.
Results£ºT2D was developed in a significantly higher percentage of patients in the ND group (53.6%) than in the control group (44.7%). The ND group increased the risk of T2D (HR, 1.43; 95% CI, 1.38-1.47). About one-third of patients in both groups were additionally diagnosed with another ND before the occurrence of T2D during a 10-year follow-up period. When compared to those who did not have another ND during the follow-up period, the incidence of T2D in those who were additionally diagnosed with another ND was higher in both the ND and control groups.
Conclusions£ºThe ND group had about 1.4 times higher risk of developing T2D than the control group. Our results showed a positive association between ND and T2D.
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KEYWORD
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Epidemiology, Cohort study, Neurodegenerative disease, Type 2 diabetes
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